Macclesfield travel to Chelsea, while Portsmouth face Wigan and Everton meet Blackburn Rovers in all-Premiership ties.
Tamworth are at home to Norwich and Salisbury, who drew with Nottingham Forest, were drawn against Charlton.
Full draw:
Blackpool v Aldershot/Basingstoke
Barnet v Colchester
Sheff Utd v Swansea
Reading v Burnley
Portsmouth v Wigan
Mansfield/Doncaster v Bolton
West Ham v Brighton
Leicester v Fulham
Derby v Wrexham
Wolves v Oldham
Bury/Chester v Ipswich
Man Utd v Aston Villa
Sheff Wed v Man City
Tamworth v Norwich
Salisbury/Nottm For v Charlton
Cardiff v Tottenham
Preston v Sunderland
Liverpool v Arsenal
Bristol Rovers/Bournemouth v Hereford
Watford v Stockport
Crystal Palace v Swindon
Bristol City v Coventry
Peterborough v Plymouth
QPR v Luton
Southend v Barnsley
West Brom v Leeds
Hull v Middlesbrough
Birmingham v Newcastle
Torquay/Leyton Orient v Southampton
Everton v Blackburn
Chelsea v Macclesfield
Stoke v Bradford/Millwall
Ties will be played on the 6 and 7 of January.