The Pilgrims have sold all their tickets and if Leeds sell their full allocation the crowd will surpass the previous best at Home Park since it was rebuilt in the 2001-02 season.
Rick Cowdery, Argyle's head of communications, said: "The current highest crowd was the 19,888 full house that attended last season's Division Two championship decider against QPR in April. But since that game the capacity of the ground has been raised to 20,922."