Joe Rodon has withdrawn from the Wales squad for Thursday's World Cup qualifier against Kazakhstan in Astana.
Rodon, along with Wrexham duo Nathan Broadhead and Danny Ward and Coventry City's Jay DaSilva all have injury issues.
Rodon, a key defensive figure for Leeds and Wales, misses out despite playing the full 90 minutes as the Whites drew 0-0 with Newcastle United last Saturday, while left-back DaSilva played the full game as Coventry drew at Oxford.
Rodon's absence leaves Ben Davies, Chris Mepham and Ben Cabango as Craig Bellamy's experienced central defensive options, alongside youngster Dylan Lawlor.
Forward Broadhead was unavailable for Wrexham's weekend win at Millwall with a calf problem, while goalkeeper Ward was expected to miss out on Wales duty after being carried off during that game.
Wales were already without Leeds' Ethan Ampadu and Burnley full-back Connor Roberts for this camp through injury, while captain Aaron Ramsey was not called up having played little club football.
