Defender Wootton, 21, left an uncertain future at Manchester United to sign a permanent deal with Leeds last week, but was an unused substitute in the weekend win at Ipswich.
McDermott is expected to make several other changes for the second-round tie, with El-Hadji Diouf hoping to make his first full appearance of the season against one of his former clubs.
Strikers Dominic Poleon and Matt Smith, defender Adam Drury and midfielder Michael Tonge are also among those in contention for a return to the starting line-up.
Doncaster's Paul Keegan will be suspended for the clash.
Keegan was sent off during Saturday's abandoned Championship fixture at Charlton. Heavy rain in south London saw the game called off at half-time with Rovers leading 3-1. While the result does not stand, under Football Associaton rules the red card does so the midfielder will miss the second round tie as he serves a one-match ban.
Dean Furman is likely to replace Keegan in what will probably be the only change that manager Paul Dickov makes to his starting line-up.
Harry Forrester has resumed training and featured in a development squad game last week but it is too early for him to be considered. Fellow midfielder Marc De Val Fernandez continues to recover from a torn medial ligament.