Salomon Olembe could make a return and Dominic Matteo is fit after a toe infection.
Portsmouth manager Harry Redknapp may bring back Eyal Berkovic to the team after withdrawing him at half-time for the 1-0 win over Manchester United.
Nigel Quashie could return to the bench with Teddy Sheringham. Petri Pasanen and Ivica Mornar are both struggling with ankle injuries.
Eddie Gray said: "It's a huge game, there's no doubt about that and it's getting to the stage now where you're desperate for points. We were disappointed with the result against Arsenal but in saying that we got beaten by a superior team in every department.
"I think it would have been more disheartening if we went somewhere and scrapped away and lost 1-0, so we've put that game behind us."
Leeds (from): Robinson, Kelly, Harte, Radebe, Camara, Duberry, Pennant, Smith, Matteo, Caldwell, Olembe, Lennon, Richardson, Domi, Kilgannon, Milner, Simon Johnson, Carson.
Portsmouth (from): Hislop, Primus, de Zeeuw, Pasanen, Stefanovic, Berkovic, Smertin, Taylor, Stone, Faye, Yakubu, LuaLua, Sheringham, Quashie, Harper, Hughes, Curtis, Mornar, Wapenaar.