However, The Whites have not won a top flight game at Pompey for 47 years, since a 5-2 success on 9th March 1957.
Seth Johnson is set to make his 200th career League appearance.
As well as Matteo, Peter Reid also hopes to be able to select both Mark Viduka and Jody Morris to his squad after they duo have been disciplined by the club.
The big Aussie's future at Elland Road is debatable as he has been linked with several moves away from Leeds.
'I got fined a few times when I was a player and it is something that happens at football clubs,' Reid said. 'Things like this happen. Unfortunately it was on a match day and it has been highlighted but it has been dealt with and I am quite happy with the situation now.
'What went on was not particularly helpful to anyone concerned but we just have to get on with it.'
Morris has been keeping up with his fitness with the help of a personal trainer.
Leeds travel by plane down to the South-Coast tomorrow.