The glamour tie at Elland Road was the pick of the third-round draw which took place on Saturday – with the meeting between the two foes the first in West Yorkshire for almost eight years.
The game will kick off at 7.45pm, with United keen for another famous night to follow on from their stunning 1-0 victory in the third round of the FA Cup back in January 2010, when Jermaine Beckford’s strike gave the Whites their first victory at Old Trafford since February 1981.
The Red Devils triumphed 3-2 after extra-time in the club’s last meeting at Leeds in October 2003, with the visitors narrowly prevailing following a close-fought Carling Cup clash, thanks to a last-gasp strike from midfielder Eric Djemba-Djemba.
Leeds have lost all their previous four matches in the League Cup’s various guises against their opponents from across the Pennines.