Martin Hodge's second string will have a strong look about it with Danny Pugh, Jermaine Beckford, Ian Moore, Dan Harding and Simon Walton all set to figure.
United have another reserve game on Thursday, at Aston Villa, and the selection for that game will give a few clues as to the possible starting line-up for the first team trip to Preston on Sunday.
Boro include Lee Cattermole, Tony McMahon, Andrew Davies, David Wheater, Jason Kennedy, Malcolm Christie and Adam Johnson in their squad for their final reserve game of the season.